Moreover, can you use Astro MixAmp with Turtle Beach?
Any headset or headphones will work with the Mixamp.
One may also ask, can you use Astros without MixAmp? Yes you can, but you loose all the surround sound. They will work just like normal stereo headphones. Do they still have surround sound if you plug them into a PC without the mixamp?
Accordingly, does Astro MixAmp make a difference?
Both will definitely improve your experience, especially if you're a streamer. But the Astro Mixamp is easier to setup and use, and a single micro-USB cable to your PC or console, an optical audio cable, and the 3.5mm headset connection are all you need to get up and running.
Is the Astro MixAmp worth it?
The Astro Gaming A40 TR headset with MixAmp Pro TR is an impressive headset/amp combination that provides excellent audio in a light and comfortable build that feels very premium. At $250 it's a very expensive package, but one that justifies its price with quality.